Abstract
Severe blood eosinophilia (16,500/mm3 and 6500/mm3) accompanied by involvement of the lungs, pleura, heart, pericardium, liver, gastrointestinal tract, peripheral nerves or skin developed in 2 patients with bronchial asthma. Associated with the eosinophilia were elevated serum Ig[immunoglobulin]E levels (1400 IU/ml and 10,500 IU/ml), depressed serum C4 [complement component 4] levels (13 mg/100 ml and 6 mg/100 ml), and high titers of rheumatoid factor (1:2560 and 1:640). Symptoms improved after treatment with prednisone and the eosinophil counts and serum IgE and C4 complement levels returned to normal.

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