Diaphragmatic blood flow at various levels of ventilation in the rabbit

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Abstract
Diaphragmatic and renal blood flow were measured with 169Yb and 46Sc labeled 15 .mu.m microspheres in sodium pentobarbitone anesthetized rabbits. The first measurement was performed during spontaneous breathing of air and the second after 15 min of breathing 2-6% CO2 in O2. The lung ventilation and the diaphragmatic blood flow increased significantly during breathing of the CO2-O2 mixture. Arterial blood pressure and renal blood flow were not significantly altered by the induced hyperventilation. No significant correlation was found between the magnitude of lung ventilation and diaphragmatic blood flow. Apparently consecutive measurements of diaphragmatic blood flow with radioactive microspheres at various levels of breathing effort is an appropriate method for further exploration of the relationship between diaphragmatic perfusion and working performance.