RESPIRATORY CONTROL AND OXIDATIVE PHOSPHORYLATION IN THE DYSTROPHIC MUSCLE

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Abstract
A study was carried out on respiratory control and oxidative phosphorylation in the muscle (homogenate) obtained by biopsy from 10 controls, 14 patients with malignant Duchenne dystrophy and 14 with other clinical forms of muscular dystrophy. In malignant Duchenne dystrophy a depressed respiratory control and normal P Ophosphate: oxygen ratio were found, characteristic of a loose coupling of oxidative phosphorylation. In the other clinical forms of muscular dystrophy evidence was found of a normal respiratory control and partial uncoupling of phosphorylation from respiration (depressed P: O ratio due to diminution in phosphorus uptake). Considerations are made with reference to the data obtained.