The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria
- 1 July 1954
- journal article
- research article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 48 (4) , 312-318
- https://doi.org/10.1016/0035-9203(54)90101-7
Abstract
The incidence of the sickle-cell trait in East Africa among 35 different native tribes is recorded. In regions where malaria is hyperendemic the incidence is over 10%, but where malaria appears only in epidemic form the incidence of the sickle-cell trait is less than 10%. Sickle-cell condition seems to be correlated with some degree of immunity to malaria.Keywords
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