Recovery of a Newly Recognized Enterovirus from Patients with Aseptic Meningitis

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Abstract
ATTEMPTS to isolate a virus in this laboratory over the past six years on stool specimens from patients with symptoms of Central-nervous-system disease have yielded 16 strains immunologically identical to an ECHO-virus candidate strain (Caldwell). This report describes illnesses in persons from whom the strains were recovered as well as serologic responses of the patients and family contacts.Materials and MethodsIsolation AttemptsThe virus strains were all isolated from stool suspensions in monkey-kidney cell cultures by a procedure described elsewhere.1 Neutralizing-Antibody AssaysPaired serum specimens from patients whose stools yielded virus and from their family contacts were assayed for . . .