EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON HUMAN-LEUKOCYTES

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 42  (1) , 16-20
Abstract
The action of 4 nonsteroidal anti-inflammatory drugs (NSAID) on the function of human polymorphonuclear neutrophils (PMN), monocytes and lymphocytes was investigated and compared to that of prednisolone. Benoxaprofen and diclofenac inhibited the chemotaxis of leukocytes in a dose-dependent fashion in vitro whereas acetylsalicylic acid and indomethacin were inactive or effective on the migration of these cells at high concentration only. Benoxaprofen did not reduce significantly (variance analysis, P = 0.05) the chemotactic locomotion of PMN or monocytes isolated from volunteers after repeated oral administration of the drug. The other functions of the leukocytes investigated, which are essential for the defense of the host, were not suppressed by NSAID at therapeutic concentrations. NSAID have a differing spectrum of biological activities and can act selectively on functions of leukocytes. The relevance of these findings to the effect of drugs on the inflammatory process is still unclear.

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