Calcium and Secretion: Distinction Between Two Pools of Glucose-Sensitive Calcium in Pancreatic Islets
- 24 December 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 194 (4272) , 1421-1423
- https://doi.org/10.1126/science.795030
Abstract
D-Glucose, but not L-glucose or 3-O-methyl-D-glucose, stimulates 45Ca2+ uptake by both lanthanum-displaceable and lanthanum-nondisplaceable pools in pancreatic islets. The nondisplaceable pool probably represents secretory granules, while the displaceable pool may be located in the beta-cell membrane. Kinetic studies with isotopically labeled islets suggest that only the displaceable pool participates in the short-term coupling of the glucose stimulus with secretion.Keywords
This publication has 9 references indexed in Scilit:
- Effects of glucose on 45Ca2+ uptake by pancreatic islets as studied with the lanthanum method.The Journal of Physiology, 1976
- Exocytosis-Endocytosis Coupling in the Pancreatic Beta CellScience, 1973
- Homocellular and heterocellular gap junctions in Limulus: A thin-section and freeze-fracture studyJournal of Ultrastructure Research, 1973
- The electron microscopic localization of cations to pancreatic islets of langerhans and their possible role in insulin secretionJournal of Ultrastructure Research, 1973
- A Threshold Distribution Hypothesis for Packet Storage of Insulin: II. Effect of CalciumDiabetes, 1972
- Calcium uptake by pancreatic -cells as measured with the aid of 45 Ca and mannitol- 3 HAmerican Journal of Physiology-Legacy Content, 1971
- Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. III. Uptake of45Calcium by Isolated Islets of Langerhans1Endocrinology, 1971