Disseminated intravascular coagulation associated with toxic epidermal necrolysis (Lyell's syndrome)

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Abstract
Evidence of disseminated intravascular coagulation was recorded in 8 patients with toxic epidermal necrolysis (TEN), Lyell''s syndrome. Patients were treated with low doses of heparin in combination with the usual treatment of TEN, i.e., maintenance of fluid and electrolyte balance, systemic corticosteroids, antibiotics and aseptic dressings, in the Intensive Care Unit environment. Apparently hemostatic changes and inter-related biological systems, i.e., activation of components of complement, kinins and immunoglobulins, may affect the outcome of TEN.