Distribution of heod (dieldrin) in mammals: II. Some applications of the preliminary model
- 1 June 1975
- journal article
- research article
- Published by Springer Nature in Archives of Environmental Contamination and Toxicology
- Vol. 3 (2) , 166-182
- https://doi.org/10.1007/bf02220786
Abstract
The preliminary model of the lipid-phase pharmacokinetics of dieldrin in mammals is applied to evaluation of the probable role of auto-induction, the effect(s) of growth, and the role of compartmentalization. Realistic simulations and comparison to actual data permit the conclusion to be drawn that induction of its own metabolism plays a relatively minor role in the distribution and level of dieldrin residues. Although some of the effects of growth are reasonably well simulated, the model as constructed does not permit compartmentalization. It was concluded that the model should be revised to include aspects of the as-yet quantitatively unknown intracellular binding and membrane transport within the flow-limited model.Keywords
This publication has 19 references indexed in Scilit:
- Distribution of HEOD (dieldrin) in mammals: I. Preliminary modelArchives of Environmental Contamination and Toxicology, 1974
- Transport and Binding of Methotrexate In VivoJournal of Pharmaceutical Sciences, 1973
- Dieldrin levels in relation to total, neutral, and phospholipid composition in selected pork musclesBulletin of Environmental Contamination and Toxicology, 1972
- Endrin and dieldrin: A comparison of hepatic excretion in the ratToxicology and Applied Pharmacology, 1970
- Influence of body weight, age, diet and sex on fat depots in ratsThe Anatomical Record, 1970
- The toxicology and pharmacodynamics of dieldrin (HEOD): Two-year oral exposures of rats and dogsToxicology and Applied Pharmacology, 1969
- Metabolic fate of dieldrin in the ratJournal of Agricultural and Food Chemistry, 1969
- The total body burden of DieldrinBulletin of Environmental Contamination and Toxicology, 1969
- Cyclodiene insecticides as inducers, substrates, and inhibitors of microsomal epoxidationJournal of Agricultural and Food Chemistry, 1968
- Toxicity and Metabolism of Dieldrin in RatsOccupational and Environmental Medicine, 1964