Seizure Remission and Antiepileptic Drug Discontinuation in Children With Tuberous Sclerosis Complex

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Abstract
TUBEROUS SCLEROSIS complex (TSC) is a genetic disorder with a variable phenotypic presentation. Some individuals have minimal stigmata and complications, and others have involvement of multiple organ systems. In TSC, there are many potential neurologic complications, including epilepsy. Epilepsy in TSC is symptomatic, with seizures arising from epileptogenic cortical tubers (hamartias) or from an epileptogenic area surrounding certain tubers.1 The severity of epilepsy in this disorder ranges from mild to catastrophic.