Prevalence of Human Herpesviruses in Patients with Aggressive Periodontitis

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Abstract
Background: Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV) and Epstein‐Barr virus type‐1 (EBV‐1), seem to play a part in the pathogenesis of human periodontitis. The aim of this investigation was evaluate the subgingival presence of HCMV and EBV in patients with aggressive periodontitis (AgP) and healthy subjects and to examine the effect of treatment on the incidence of these viruses months following surgery.Methods: A polymerase chain reaction (PCR) method determined the presence of HCMV and EBV‐1. Subgingival plaque samples from 17 consecutive AgP patients and 16 healthy controls were collected. The following indices were measured: plaque index (PI), gingival index (GI), probing depths (PD), and clinical attachment loss (CAL). Clinical parameters were assessed pretherapy and at 3 months following surgical and antimicrobial therapy.Results: HCMV was detected in 64.7% of AgP patients but not detected in healthy subjects (P P P Conclusions: These findings indicate that subgingival presence of EBV‐1 HCMV is strongly associated with aggressive periodontitis, and coinfection with HCMV and EBV‐1 appears to be particularly deleterious to periodontal health. J Periodontol 2003;74:1634‐1640.