Cytotoxic α/β+ and γ/δ+ T cells in murine intestinal epithelium
- 1 July 1990
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 20 (7) , 1623-1626
- https://doi.org/10.1002/eji.1830200734
Abstract
Murine intraepithelial lymphocytes (IEL) consist of two main populations. Approximately half are Thy-1+, most of which are CD3+, T cell receptor (TcR) α/β+, and the remainder are Thy-1−, most of which are CD3+, TcR α/β (presumably TcR γ/δ+). In redirected cytotoxicity assays, TcR α/β+ IEL are potent cytotoxic effectors. Thy-1−, CD3+, TcR α/β− IEL isolated from athymic mice are also cytotoxic. Thus, regardless of TcR usage or Thy-1 expression, IEL are cytotoxic effectors.This publication has 16 references indexed in Scilit:
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