Bicarbonate-responsive “soluble” adenylyl cyclase defines a nuclear cAMP microdomain
Open Access
- 9 February 2004
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 164 (4) , 527-534
- https://doi.org/10.1083/jcb.200311119
Abstract
Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.Keywords
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