Pharmacokinetics of cinoxacin in normal volunteers and patients with impaired renal function

Publisher Website
Google Scholar
Abstract
The pharmacokinetics of cinoxacin, a new synthetic antibacterial agent, was studied in 6 normal volunteers and 18 patients with impaired renal function after a single 400 mg oral dose. The pharmacokinetic parameters of cinoxacin were obtained by analysing the serum level data of cinoxacin based on a one-compartment open model. The mean serum half-life of cinoxacin was 1·1 h in normal subjects and was prolonged to 12·1 h in patients on hemodialysis. There was a significant linear correlation (P<0·001) between the elimination rate constant of cinoxacin and the creatinine clearance. In normal subjects, 62% of the administered dose was excreted as free cinoxacin in the 12-h urine.

This publication has 0 references indexed in Scilit: