Esterification of cholesterol and hydrolysis of cholesteryl ester in alcohol induced fatty liver of rats
- 1 May 1974
- Vol. 9 (5) , 353-357
- https://doi.org/10.1007/bf02533113
Abstract
Repeated oral administrations of ethanol to rats induced accumulation of cholesteryl ester, as well as triglyceride in the livers. The contents of free cholesterol and phospholipid in the livers were not changed significantly in the present experiment in which ethanol ingestions were repeated four times. Although in vitro esterification of cholesterol by particle fractions of the alcoholic fatty liver was not affected, hydrolysis of cholesteryl palmitate by the supernatant fraction of the liver homogenate was reduced when compared with those of the control group which was given water or isocaloric glucose. The results of in vitro esterification of cholesterol and hydrolysis of cholesteryl palmitate in the liver of the rats which were ingested with glucose were larger than those of the control rats which were given water.Keywords
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