Augmented Expression of Cardiotrophin-1 in Failing Human Hearts Is Accompanied by Diminished Glycoprotein 130 Receptor Protein Abundance
- 17 September 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 106 (12) , 1442-1446
- https://doi.org/10.1161/01.cir.0000033117.39335.df
Abstract
Background— Cardiotrophin-1 (CT-1), a member of the interleukin-6 superfamily, is a potent inducer of cardiomyocyte hypertrophy that prolongs myocyte survival. Although cardiac CT-1 gene expression...Keywords
This publication has 14 references indexed in Scilit:
- Non-competitive immunochemiluminometric assay for cardiotrophin-1 detects elevated plasma levels in human heart failureClinical Science, 2002
- Oncostatin M Regulates the Synthesis and Turnover of gp130, Leukemia Inhibitory Factor Receptor α, and Oncostatin M Receptor β by Distinct MechanismsJournal of Biological Chemistry, 2001
- Suppressor of cytokine signaling-3 is a biomechanical stress–inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathwaysJournal of Clinical Investigation, 2001
- The Heart Is a Source of Circulating Cardiotrophin-1 in HumansBiochemical and Biophysical Research Communications, 2000
- Elevated circulating cardiotrophin-1 in heart failure: relationship with parameters of left ventricular systolic dysfunctionClinical Science, 2000
- An Immunoluminometric Assay for Cardiotrophin-1: A Newly Identified Cytokine Is Present in Normal Human Plasma and Is Increased in Heart FailureBiochemical and Biophysical Research Communications, 1999
- Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent PathwayJournal of Biological Chemistry, 1997
- Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell HypertrophyJournal of Biological Chemistry, 1996
- Cardiotrophin-1Journal of Biological Chemistry, 1995
- Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.Proceedings of the National Academy of Sciences, 1995