Toxicity and Metabolism of Naphthalene: A Study with Marine Larval Invertebrates

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Abstract
[1-14C]Naphthalene and [1-14C]naphthalene complexed with BSA [bovine serum albumin] at 8-12 ppb in flowing sea water produced 100% mortality in 24-36 h in newly hatched Dungeness crab (Cancer magister) zoea and stage I and V spot shrimp (Pandalus platyceros). Maximum accumulation of [1-14C]naphthalene in stage V spot shrimp exposed to [1-14C]naphthalene was nearly 4 times greater than in shrimp exposed to the [1-14C]naphthalene-BSA complex (820 and 220 ppb, respectively). These values represent a magnification of 25-100 times the exposure levels. Metabolic products of [1-14C]naphthalene in larval tissues exposed to complexed and noncomplexed naphthalene reached a maximum of 21 and 9%, respectively, of the total radioactive compounds (based on the MW of naphthol). [1-14C]Naphthalene was almost entirely depurated from the tissues in 24-36 h, but metabolic products were strongly resistant to depuration.

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