BINDING OF AGGREGATED IgG TO NEPHRITOGENIC TYPE 12 STREPTOCOCCI: INFLUENCE OF SERUM, C1 AND C4

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Abstract
The uptake of aggregated [human] Ig[immunoglobulin]G by type 12, M protein positive (M + ve) streptococci was high in the presence of fresh serum, while the uptake by type 12, M - ve, type 1 and type 2, M + ve or M - ve streptococci was inhibited. Serum heated to 56.degree. C for 30 min inhibited the uptake of aggregated IgG by all strains tested. Purified C1q [q fragment of complement component 1] or macromolecular C1 added to heat-treated serum reinstituted the uptake of aggregated IgG. C1 and C4 in fresh serum influenced the uptake of aggregated IgG by streptococci, resulting in the distinct reaction patterns observed. [The importance of the results to the study of acute poststreptococcal nephritis is discussed.].

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