Molecular pathology of low grade malignant lymphomas
- 1 September 1995
- journal article
- Published by Springer Nature in Medical Oncology
- Vol. 12 (3) , 167-176
- https://doi.org/10.1007/bf01571194
Abstract
During the last ten years the combined efforts of pathologists and molecular biologists have helped define several new lymphoma diagnostic categories. In particular, the recognition of chromosomal translocations which have activated the BCL1 and BCL2 proto-oncogenes have strong associations with specific types of non-Hodgkin’s malignant lymphomas such as mantle cell lymphoma and follicular center cell lymphoma, respectively. This review will attempt to summarize our current understanding regarding the contributions of BCL1 and BCL2 to lymphomagenesis and diagnosis.Keywords
This publication has 67 references indexed in Scilit:
- Follicular Small Lymphocytic LymphomaThe American Journal of Surgical Pathology, 1994
- Rearrangement of the Rheumatoid Factor-Related Germline Gene Vg and bcl-2 Expression in Lymphoproliferative Disorders in Patients with Sjögren's SyndromeClinical Immunology and Immunopathology, 1994
- bcl-2 Protein Expression and Correlation with the Interchromosomal 14;18 Translocation in Cutaneous Lymphomas and PseudolymphomasJournal of Investigative Dermatology, 1994
- bcl-2 Gene Rearrangement Analysis of Japanese Follicular Lymphomas by Polymerase Chain Reaction in Formalin-fixed, Paraffin-embedded Tissue SpecimensJapanese Journal of Cancer Research, 1993
- Translocation (14; 18) and (8; 22) in three patients with acute leukemia/lymphoma following centrocytic/centroblastic non-Hodgkin's lymphomaAnnals of Hematology, 1991
- Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosisEuropean Journal of Immunology, 1991
- Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell deathCell, 1991
- bcl-2Translocation in Japanese B Cell Lyraphoma: Novelbcl-2Translocation with Immunoglobulin Heavy Chain Diversity SegmentJapanese Journal of Cancer Research, 1991
- Expression in Non-Hodgkin's Lymphoma of thebcl-2 Protein Associated with the t(14;18) Chromosomal TranslocationNew England Journal of Medicine, 1988
- Patterns of chromosome breakage in nonHodgkin lymphoma: significance to gene alteration in tumorigenesisCytogenetic and Genome Research, 1987