A DNA polymorphism of the apoprotein AII gene in hypertriglyceridaemia
- 1 November 1986
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 74 (3) , 302-306
- https://doi.org/10.1007/bf00282553
Abstract
A polymorphism of the apolipoprotein AII gene (on chromosome 1) was investigated using genomic hybridisation analysis. The two common alleles at this locus were defined by MspI restriction fragments of 3.0 kilobase pairs (M3.0) and 3.7 kilobase pairs (M3.7) respectively. The M3.7 allele was significantly more common (PP<0.05) in subjects with disease-associated alleles of both the Apo CIII and Apo AII genes, compared with subjects with a disease-associated allele of one or neither locus.Keywords
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