REDOX REGULATION OF c-Ha-ras AND OSTEOPONTIN SIGNALING IN VASCULAR SMOOTH MUSCLE CELLS: Implications in Chemical Atherogenesis
- 1 April 1999
- journal article
- review article
- Published by Annual Reviews in Annual Review of Pharmacology and Toxicology
- Vol. 39 (1) , 243-265
- https://doi.org/10.1146/annurev.pharmtox.39.1.243
Abstract
▪ Abstract Reduction/oxidation (redox) reactions play a central role in the regulation of vascular cell functions. Recent studies in this laboratory have identified c-Ha-ras and osteopontin genes as critical molecular targets during oxidant-induced atherogenesis. This review focuses on the deregulation of gene transcription by redox-activated trans-acting factors after benzo(a)pyrene challenge and the modulation of extracellular matrix signaling in vascular smooth muscle cells by allylamine-induced oxidative injury. The induction of atherogenic vascular smooth muscle cell phenotypes by chemical injury exhibits remarkable parallels with those seen in other forms of atherogenesis.Keywords
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