Neuronal responses to extracellularly applied cyclic AMP: Role of the adenosine receptor

1 April 1978

journal article
research article
Published by Springer Nature in Cellular and Molecular Life Sciences

Vol. 34 (4) , 481-482
https://doi.org/10.1007/bf01935940

Abstract

At low doses, theophylline blocks the neuronal depressant effects of 5′-AMP, but not cyclic AMP. Higher doses (100 mg/kg) block cyclic AMP responses and reduce the effects of noradrenaline and GABA. It is concluded that cyclic AMP does not depress neurones via the adenosine receptor.

Keywords

This publication has 13 references indexed in Scilit:

Microiontophoretic studies of the effects of cyclic nucleotides on excitability of neurones in the rat cerebral cortex
The Journal of Physiology, 1977
Electrophysiology and cytology of hippocampal formation transplants in the anterior chamber of the eye. II. Cholinergic mechanisms
Brain Research, 1977
Adenosine-dependent formation of cyclic AMP in brain slices
Pharmacological Research Communications, 1976
Adenosine as a putative transmitter in the cerebral cortex. Studies with potentiators and antagonists
Life Sciences, 1975
Cyclic AMP and Cyclic GMP May Mediate Opposite Neuronal Responses in the Rat Cerebral Cortex
Science, 1975
The role of cyclic nucleotides in central synaptic function
Published by Springer Nature ,1975
Depression of Corticospinal Cells by Various Purines and Pyrimidines
Canadian Journal of Physiology and Pharmacology, 1974
The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies
Brain Research, 1974
CYCLIC AMP MEDIATION OF NOREPINEPHRINE INHIBITION IN RAT CEREBELLAR CORTEX: A UNIQUE CLASS OF SYNAPTIC RESPONSES
Annals of the New York Academy of Sciences, 1971
INCREASE IN THE CONTENT OF ADENOSINE 3′5′‐ MONOPHOSPHATE IN MOUSE FOREBRAIN DURING SEIZURES AND PREVENTION OF THE INCREASE BY METHYLXANTHINES
Journal of Neurochemistry, 1971