Distribution Characteristics of Ethosuximide in Discrete Areas of Rat Brain

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Abstract
The distribution properties of ethosuximide [an anticonvulsant] in 4 regions of the rat brain, cortex, midbrain, cerebellum and pons-medulla, were investigated following chronic i.p. administration of the drug (every 12 h for 108 h) at 4 dose levels (20, 40, 60 and 80 mg/kg). A GLC procedure was developed to quantitate ethosuximide levels in these tissues and plasma. The mean tissue/plasma ratios were 0.917, 0.942, 0.902 and 0.903 for cortex, midbrain, cerebellum and pons-medulla, respectively. The distribution ratio for midbrain was significantly greater than that observed for cerebellum. For each brain region the distribution ratio was independent of dose (20-80 mg/kg) and plasma concentration (8-135 .mu.g/ml).