Biological Significance of Nonlymphocytic Oligoblastic Leukemia

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Abstract
Kinetic studies of marrow dividing granulocytic precursors (mitotic index [MI] and flash labeling index [LI] with 3H-TDR) were carried out in 11 patients with oligoblastic leukemia (OBL). The results were compared with similar data from cases of conventional acute non-lymphocytic leukemia (ANLL). The cytokinetic results were as follows: MI (%) in OBL, mean = 0.75; MI (%) in ANLL, mean = 0.66; P > 0.7; LI (%) in OBL, mean = 15.0; LI (%) in ANLL, mean = 15.4, P > 0.7. The lack of cytokinetic differences between these 2 groups of patients stands in favor of the hypothesis that OBL might represent a special type of smoldering leukemia with a plateau of blast cell accumulation established at a subleukemic level.

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