THE INFLUENCE OF ADRENALECTOMY AND INDIVIDUAL STEROID HORMONES UPON THE METABOLISM OF ACETATE-1-C14 BY RAT LIVER SLICES: III. RESPIRATORY EFFECTS

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Abstract
The oxidation of acetate-1-C14 by rat liver slices was found to be raised above the control level in both sham-operated and adrenalectomized animals. Deoxycorticosterone further increased substrate oxidation in the adrenalectomized group, but had no effect upon sham-operated animals. No other hormone investigated influenced the oxidation of acetate. The respiratory rate of liver slices was elevated by adrenalectomy: cortisone and deoxycorticosterone lowered the respiratory rate of sham-operated animals. A comparison has been made with the effects of certain esterified steroids. These were, in general, observed to be less stimulatory in effect than the corresponding alcohols, and in some cases caused considerable inhibition of respiration.