ALBRIGHT'S HEREDITARY OSTEODYSTROPHY

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Abstract
Different clinical forms of Albright''s hereditary osteodystrophy were observed in 4 members of a family (2 sisters, their mother and the maternal grandfather). The sisters were affected by pseudohypoparathyroidism type I, the older manifested the hypocalcemic variety, the younger the normocalcemic variety; the mother and the grandfather presented only with short stature and subcutaneous calcifications. The variety of clinical and biochemical alterations observed in these 3 generations supports evidence that Albright''s hereditary osteodystrophy has a broad spectrum and that distinctions between the various forms of pseudohypoparathyroidism should not be rigidly considered.