Metabolic Dehydrogenation ofcis- andtrans-Acenaphthene-I,2-diol

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Abstract
1. The dehydrogenation of cis- and trans-acenaphthene-1,2-diol to ace-naphthenequinone by rat liver microsomal preparations has been established by means of chromatography and isolation. 2. The formation of acenaphthenequinone or a carbonyl precursor of it during incubation of the diols with rat liver microsomes has been followed by a spectrophotometric method and has been shown to be assisted by NAD+ to a greater extent than by NADP+. 3. 1,8-Naphthalic aldehyde was not found as a result of microsomal action on the acenaphthenediols, but under certain conditions 1,8-naphthalic acid was detected in incubation mixtures. 4. Trace amounts of acenaphthenequinone and large amounts of 1,8-naphthalic acid were found in the urine of rats injected with cis- or trans-acenaphthene-1,2-diol or acenaphthenequinone.