Absence of Need for Amniocentesis in Patients with Elevated Levels of Maternal Serum Alpha-Fetoprotein and Normal Ultrasonographic Examinations

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Abstract
Recent improvements in the accuracy of sonographic diagnosis of neural-tube and ventral-wall defects have raised a question about the wisdom of routinely offering amniocentesis to women who have elevated levels of maternal serum alpha-fetoprotein with a structurally normal fetus as determined by ultrasonography.