Molecular Relatedness of Mammalian RNA Tumor Viruses as Determined by DNA ⋅ RNA Hybridization

1 June 1973

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 180 (4089) , 972-974
https://doi.org/10.1126/science.180.4089.972

Abstract

Each of six mammalian C-type viruses—including two feline leukemia viruses, three murine leukemia viruses, and the human "candidate" virus RD-114—can be distinguished from each other by hybridizing DNA synthesized by viral reverse transcriptase with viral RNA. Characterization of the DNA · RNA hybrids by hydroxylapatite chromatography revealed nucleotide sequence diversity among the viruses, detectable both by the amount of cross-hybridization and by the decreased thermal stability of heterologous hybrids.

Keywords

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