Anatomy and Pathophysiology of Peyronie’s Disease and Congenital Deviation of the Penis

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Abstract
42 specimens from resected plaques of Peyronie’s disease (IPP) and connective tissue obtained according to Nesbit were examined microscopically. The specimens were divided into three layers and the respective structures were counted in each layer in 15 fields of view with 100-fold magnification. 14 of 20 patients i.e. 70% of patients with IPP showed more than 10 perivascular infiltrates of lymphocytes and plasma cells/45 fields. 60% of all infiltrates were localized in the mid portions. 30% in the dorsal aspect and only 10% in the lower layers near the corpus spongiosum, where IPP is supposed to have its origin. A significant reduction of the quantity of inflammatory infiltrates related to the duration of the disease could not be proved. The same applies to vascular sections. The total numer of vascular cross-sections found in the IPP plaque is 3 times as high as in the macroscopically inconspicuous tissue obtained according to Nesbit. 61% of blood vessels were localized in the mid portion, 22.3% in the dorsal aspect and only 16.5% in the basel portion near the corpus spongiosum. Bone formation was found in 4 of the 20 analyzed specimens from patients with IPP. These quantitative morphological studies have shown that the plaque undergoes reactive processes which even persist after years.

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