Objective measurements of haze following phototherapeutic excimer laser ablation of cornea

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Abstract
We report on the use of a recently developed scatterometer to make objective measurements of haze that develops following excimer laser ablation of cornea. Phototherapeutic keratectomies (PTK), 6.0 mm dia, 0.25 mm transition zone, 150 micrometers stromal depth, were done on 4 pigmented rabbits using the VISX Model 20/20 laser system. Scatterometer measurements were made on the normal cornea prior to ablation and at various times up to 125 days postablation and are compared to slit-lamp photographs. Scattering from 3 of the eyes exhibited nearly identical behavior, peaking 20-25 days after treatment at 10 to 12 times the preablation level and then diminishing slowly. Scattering from the fourth eye peaked 14 days after treatment at 28 times the preablation level and remained well above the level of the other three eyes throughout the experimental period. These results suggest that identical PTK treatments can lead to different degrees of subepithelial haze.

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