A Metabolite of Riboflavin Binds to the 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Receptor
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 30 (5) , 241-244
- https://doi.org/10.1159/000138073
Abstract
A cytosolic receptor to which TCDD binds with high affinity has been reported in a number of rodent tissues, but the endogenous/natural ligand is not known. However, lumichrome, a metabolite of riboflavin, competed with 3H-TCDD for binding to the cytosolic receptor. Neither riboflavin nor riboflavin-5-phosphate competed for binding to the TCDD receptor in rat liver cytosol. Lumichrome is the first known endogenous chemical in the rat to exhibit affinity for the TCDD receptor.Keywords
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