Influence of Phenylbutazone on Gastric Secretion of Mucus.

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Abstract
The mechanism by which the therapeutic use of phenylbutazone sometimes causes gastric mucosal injury in the form of hemorrhage, erosions or ulcerations was studied. Mucoid secretions from gastric-antral pouches of dogs were studied before, during and after the oral administration of phenylbutazone in doses of 100 mg/kg of body weight. This drug decreased the rate of mucus secretions and the carbohydrate to protein ratio in non-dialyzable mucosubstance. Gastric mucosal injury by phenylbutazone may be due to altered mucosal defense mechanisms.