Synthesis and Biophysical and Biological Evaluation of 2′-Modified Antisense Oligonucleotides

1 January 1991

journal article
oral communications
Published by Taylor & Francis in Nucleosides and Nucleotides

Vol. 10 (1-3) , 259-262
https://doi.org/10.1080/07328319108046455

Abstract

A series of 2′-deoxy-2′-substituted adenosine modified oligonucleotides were synthesized and evaluated for their thermodynamic stability (Tms) and resistance to nuclease degradation in fetal calf serum.

Keywords

TMS
THERMODYNAMIC
ADENOSINE
CALF
NUCLEASE
ANTISENSE
FETAL
SUBSTITUTED
BIOPHYSICAL
DEOXY