Mupirocin resistance among consecutive isolates of oxacillin-resistant and borderline oxacillin-resistant Staphylococcus aureus at a university hospital
Open Access
- 1 July 1994
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 38 (7) , 1664-1667
- https://doi.org/10.1128/aac.38.7.1664
Abstract
Mupirocin resistance was determined in consecutive oxacillin-resistant and borderline oxacillin-resistant Staphylococcus aureus clinical isolates collected over 14 months at a university hospital during 1991 and 1992. Twenty of 86 (23%) oxacillin-resistant and borderline oxacillin-resistant S. aureus isolates were mupirocin resistant; 80% were high-level resistant. Prior mupirocin use was a significant risk factor (relative risk, 6.08; 95% confidence interval, 3.7 to 9.99). Seven of 20 resistant isolates were distinct strains, as determined by pulsed-field gel electrophoresis typing. Two instances of clonal dissemination of a single strain occurred, but several other distinct mupirocin-resistant strains were documented. Mupirocin resistance was unexpectedly common among these isolates.Keywords
This publication has 26 references indexed in Scilit:
- An Outbreak of Mupirocin-ResistantStaphylococcus aureuson a Dermatology Ward Associated with an Environmental ReservoirInfection Control & Hospital Epidemiology, 1993
- The use of nasal mupirocin ointment to prevent Staphylococcus aureus bacteraemias in haemodialysis patients: an analysis of cost-effectivenessJournal of Hospital Infection, 1991
- Reduction in the colonization of central venous cannulae by mupirocinJournal of Hospital Infection, 1991
- Mupirocin resistanceThe Lancet, 1991
- Cloning of the gene conferring resistance to mupirocin in Staphylococcus aureusFEMS Microbiology Letters, 1991
- Use of mupirocin ointment in the treatment of secondarily infected dermatosesJournal of the American Academy of Dermatology, 1990
- A bacteriologically controlled, randomized study comparing the efficacy of 2% mupirocin ointment (Bactroban) with oral erythromycin in the treatment of patients with impetigoJournal of the American Academy of Dermatology, 1990
- Mupirocin-resistant Staphylococcus aureus after long-term treatment of patients with epidermolysis bullosaJournal of the American Academy of Dermatology, 1990
- Transferable mupirocin-resistanceJournal of Antimicrobial Chemotherapy, 1988
- NASAL CARRIAGE OF GENTAMICIN AND METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS TREATED WITH TOPICAL PSEUDOMONIC ACIDPublished by Elsevier ,1983