Prazosin Does Not Alter Levels of Plasma Lipids, Glucose, and Insulin

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Abstract
In a double-blind, randomized, cross-over study involving 15 mild hypertensive patients, the effects of prazosin (5.7 mg/day) and placebo on plasma levels of lipids, lipoproteins, glucose and insulin were compared. After 5 wk of treatment, prazosin had not significantly altered the mean levels of plasma cholesterol, phospholipids and triglycerides in the high-density lipoprotein or low-density lipoprotein plus very low-density lipoprotein subfractions. Fasting and postload plasma levels of glucose and insulin were also unaffected.

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