An economical and versatile synthesis of 5,8-dialkoxy-2-acetyl-3,4-dihydronaphthalenes: key precursors for the synthesis of chiral anthracyclines
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 994-995
- https://doi.org/10.1039/c39830000994
Abstract
5,8-Diacetoxy-2-acetyl-3,4-dihydronaphthalene, prepared by a new route from the Diels–Alder adduct of buta-1,3-diene and p-benzoquinone, is selectively deacetylated (Cs2CO3 in tetrahydrofuran or K2CO3 in dimethyl sulphoxide) to intermediates suitable for use in chiral anthracycline synthesis.Keywords
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