Modification and Exploitation of a Poliovirus-induced Membrane Complex by Superinfecting ME Virus

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Abstract
The replication of mouse Elberfeld (ME) virus was accelerated when HEp-2 [human laryngeal carcinoma] cells were mixedly infected with poliovirus in the presence of guanidine. The latent period of the replication of ME virus was shortened by 3 h when cells were preinfected for at least 2 h with poliovirus and inhibited by guanidine. Simultaneous infection with poliovirus and ME virus resulted in a shortening by 1 h of the latent period of ME virus replication. The accelerated replication of ME virus was due to modification and exploitation of a membrane complex induced by poliovirus in the presence of guanidine; on superinfection ME virus successively modified this poliovirus-induced complex of 470S (light complex) into a heavy complex of 700S specific for ME virus.