Induction of Intestinal Carcinoma in the Rat by X-Irradiation of the Small Intestine

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Abstract
The exteriorized ileum and jejunum of male Holtzman rats were x-irradiated with 1000 to 2500 r. The superior mesenteric artery and vein were clamped during exposure in some irradiated animals. Per cent survival at 30 days was increased by the blood restriction procedure in all cases where there was some mortality due to irradiation alone. Over 50% of the irradiated animals which survived above 1400r because of the clamping procedure developed low grade intestinal adenocarcinoma. Tumors appeared as early as 55 days and as late as 225 days post-irradiation. Metastases were seen in only two animals. Animals without surgery or irradiation and those subjected to the intestinal vessel clamping procedure alone did not develop tumors.