Amplified asymmetric dihydroxylation of a racemic cyclopentene
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 1501-1502
- https://doi.org/10.1039/c39950001501
Abstract
Racemic cyclopenteno-1,2,4-trioxane 1/ent-1 by iterative dihydroxylation with N-methylmorpholine N-oxide in the presence of catalytic amounts of K2OsO4 and (DHQD)2PHAL in aqueous Me2 CO at 25 °C gives essentially enantiomerically pure diols 2(96% e.e.) and ent-2(98% e.e.) in yields of 31.5 and 43%, respectively.Keywords
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