Semisyntheses, X-Ray Crystal Structures and Tubulin-Binding Properties of 7-Oxodeacetamidocolchicine and 7-Oxodeacetamidoisocolchicine

1 January 1992

journal article
Published by CSIRO Publishing in Australian Journal of Chemistry

Vol. 45 (10) , 1577-1588
https://doi.org/10.1071/ch9921577

Abstract

Commercially available (–)-colchicine (1) has been converted, via deacetylcolchiceine (4), into a mixture of 7-oxodeacetamidocolchicine (2) and 7-oxodeacetamidoisocolchicine (3). The X-ray structures and tubulin-binding properties of these title ketones are described.

Keywords

CRYSTAL STRUCTURES
SEMISYNTHESES
RAY CRYSTAL
BINDING PROPERTIES
TUBULIN BINDING
OXODEACETAMIDOCOLCHICINE
OXODEACETAMIDOISOCOLCHICINE

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