SUPPRESSION OF HEMOPOIETIC COLONY-FORMING UNITS IN MICE BY GRAFT-VERSUS- HOST REACTIONS

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Abstract
SUMMARY Attempts to characterize the time course of parental-versus-F1 hybrid immunological reactions in sublethally irradiated mice have resulted in the following observations. (1) It was possible to reverse the lethal effect of the reaction by means of a second dose of X-rays delivered up to 4 days after injection of the parental lymphoid cells. In contrast, mice irradiated 5 days or later succumbed to the disease. (2) Nonirradiated host-type colony-forming units in the spleens of mice undergoing the parental-F1 hybrid disease were depleted at 5 days, and in the marrow by 7 days. (3) It was not possible to reverse the lethal course of the disease with large doses of host type hemopoietic cells injected 3-6 days after injection of the parental cells.

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