Expression of la‐Like Antigen in Lymphatic Leukaemias and Non‐Hodgkin Lymphomas in Correlation with Other Surface Markers

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Abstract
Ia‐like antigen, surface Ig, E‐rosettes, mouse red blood cell rosettes and further surface markers were investigated in 88 specimens from 69 patients with various lymphocytic leukaemias and non‐Hodgkin lymphomas.Ia‐like antigen was detectable in all cases of sIg+ leukaemias and lymphomas. E‐la+sIg‐ leukaemias, especially CLL and lymphomas were interpreted as ß‐cell neoplasias, which either did not produce sIg or expressed it in undetectable amounts. E+Ia+sIg+ malignant lymphocytes represented a ß‐cell population with antibody activity of sIg to SRBC. In the present series 9.5 % of all ß‐cell leukaemias and lymphomas demonstrated this phenotype. Whereas ALL may possess Ia‐like antigen, the vast majority of mature T‐cell lymphomas are lacking it. In the present series 2 T‐cell lymphomas expressed Ia‐like antigen and did not contain TdT (E+Ia+sIg‐TdT‐). These lymphomas are probably derived from a stimulated T‐cell clone synthesizing Ia‐like antigen.