EFFECT OF GROWTH HORMONE ON THE NITROGEN EXCRETION AND BODY WEIGHT OF ADULT FEMALE RATS1

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Abstract
The fact that the hypophyseal growth hormone produces nitrogen retention and body weight gain in rats is well established. That it is capable of producing continuous growth in normal adult female rats has likewise been established (Evans, Simpson, and Li, 1948). Using a crude growth hormone preparation, Collip (1934) found that when normal rats were continually injected with the same amount of hormone they became refractory to the nitrogen-retaining, weightenhancing effect of the preparation. The present study was undertaken to establish whether the continual injection into normal rats of small doses of pure growth hormone would be associated with the development of a refractory state to either the weight-increasing or the nitrogen-retaining effect of the hormone. methods The hormone preparation used was prepared according to the previouslypublished method (Li, Evans and Simpson, 1945) and ½ of the total daily dose was given intraperitoneally each morning and evening.