Four New Bioactive Pyrrole-Derived Alkaloids from the Marine Sponge Axinella brevistyla

Abstract
Four new alkaloids (1−4) were isolated from the marine sponge Axinella brevistyla, and their structures were determined on the basis of spectroscopic analysis. The alkaloids 1−4 were antifungal against the yeast Saccharomyces cerevisiae at 50 values of 1.1, 0.66, and 2.5 μg/mL, respectively.