PREVENTION BY SOMATOSTATIN OF RISE IN BLOOD PRESSURE AND PLASMA RENIN MEDIATED BY BETA-RECEPTOR STIMULATION

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Abstract
The interrelationships of increased plasma renin and elevated blood pressure following acute .beta.-stimulation by orciprenaline and its prevention by somatostatin was studied in normal man. During somatostatin infusion basal values of renin and blood pressure were unchanged. Following orciprenaline both variables increased significantly. Combination of somatostatin and orciprenaline reduced the rise in plasma renin activity by 49%, mean arterial blood pressure by 21% and heart rate by 19%, compared with .beta.-stimulation alone. The inhibitory action of somatostatin on plasma renin activity may be mediated via .beta.-receptors. The lesser increase of blood pressure under somatostatin plus orciprenaline also indicates a possible inhibitory effect of somatostatin on .beta.-adrenergic receptors.