Preferential Solvation Study of Polyvinylpyrrolidone in Organic or Aqueous Mixed Solvents by GPC

Abstract
This paper deals with the use of gel permeation chromatography for the determination of the preferential solvation of polyvinylpyr-rolidone in binary solvent mixtures. It is the first time that this technique is applied to preferential solvation in both organic and aqueous systems. With this rapid and accurate method, we determined values of the preferential solvation coefficient λ1, which are compared with those obtained by light scattering or dialysis equilibrium.