Engineering chromosomal rearrangements in mice
- 1 October 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 2 (10) , 780-790
- https://doi.org/10.1038/35093564
Abstract
The combination of gene-targeting techniques in mouse embryonic stem cells and the Cre/loxP site-specific recombination system has resulted in the emergence of chromosomal-engineering technology in mice. This advance has opened up new opportunities for modelling human diseases that are associated with chromosomal rearrangements. It has also led to the generation of visibly marked deletions and balancer chromosomes in mice, which provide essential reagents for maximizing the efficiency of large-scale mutagenesis efforts and which will accelerate the functional annotation of mammalian genomes, including the human genome.Keywords
This publication has 48 references indexed in Scilit:
- MOLECULAR MECHANISMS FOR CONSTITUTIONAL CHROMOSOMAL REARRANGEMENTS IN HUMANSAnnual Review of Genetics, 2000
- The 22q11 deletion syndromesHuman Molecular Genetics, 2000
- Dual Renin Gene Targeting by Cre-Mediated Interchromosomal RecombinationGenomics, 2000
- Predetermined chromosomal deletion encompassing the Nf-1 geneOncogene, 1999
- Generation and Characterization of Heritable Reciprocal Translocations in MiceMethods, 1997
- A comprehensive genetic map of the mouse genomeNature, 1996
- Chromosome engineering in miceNature, 1995
- A mouse model for Down syndrome exhibits learning and behaviour deficitsNature Genetics, 1995
- Chromosomal translocations in human cancerNature, 1994
- Autosomal Translocations Causing Male Sterility and Viable Aneuploidy in the MouseCytogenetic and Genome Research, 1966