Resetting of osmoreceptor response as cause of hyponatraemia in acute idiopathic polyneuritis.

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Abstract
In a patient with hyponatraemia associated with acute idiopathic polyneuritis plasma concentrations of antidiuretic hormone increased when hypertonic saline was infused intravenously, and urine osmolality rose concomitantly. A water load was excreted normally, while the plasma remained extremely hypo-osmolal. It is concluded that osmoregulation was functioning normally but was set abnormally low, possibly owing to a disturbance of the peripheral volume receptors.