Effect of potassium-induced diuresis on renal concentration and dilution

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Abstract
Parenteral administration of KC1 may result in a diuresis with an increase in the rate of excretion of sodium, chloride, potassium, and bicarbonate. In order to localize the nephron segment in which potassium exerts these effects, the alterations in T[image] and CH2O resulting from a potassium-induced diuresis were examined. In dehydrated dogs given vasopressin, a NaCl infusion was administered at progressively increasing rates and the T[image] -Cosm relationship observed. After T[image] and Cosm had stabilized, a potassium-induced diuresis was superimposed on the NaCl diuresis during either a "relative plateau" of the T[image] orr during a falling T[image]. In the former situation, [DELTA]T[image]/[DELTA] Cosm increased, and, in the latter studies, the decline in T[image] was arrested and [DELTA] T[image]/[DELTA] Cosm became positive. During water diuresis, the increased solute excretion following the infusion of KC1 was associated with a fall in free water ( [DELTA]CH2O/[DELTA] Cosm =[long dash]0.75, r =[long dash]0.92). It is concluded that the changes in T[image] and CH2o, following KC1 administration are due to a decrease in net ionic reabsorption in the distal convoluted tubules.